Development of an Efficient and Affordable Protein Purification System to Study Protein Functions and Structures

This technology includes a semi-automatic and affordable protein purification system that produces purified proteins with yields and purities comparable to an automatic protein purification system for less than 10% of its cost, which can be used for studying protein structure and function, as well as antibody purifications and drug screenings. Additionally, the new system is flexible and customizable for use with both custom-made and commercial pre-made resin columns with either gravity flow or low-pressure configurations.

A Method to Guide Protocol Development for Magnetic Resonance Thermometry

This technology includes tools to guide optimization of thermometry imaging/post-processing protocols. Proton Resonance Frequency (PRF) thermometry is a widely used Magnetic Resonance Imaging (MRI) based technique to monitor changes in tissue temperature in response to thermal therapy. The use of PRF thermometry with thermal therapy procedures is indispensable to ensure delivery of desired thermal dose to the target tissue, and to minimize unintended damage to the normal tissue.

Devices for Improved Tissue Cryopreservation and Recovery

Problem: Cryopreservation is a process where living biological materials like cells, tissues, and cell therapies (which are susceptible to damage caused by unregulated chemical kinetics) are preserved by cooling to very low temperatures in the presence of specific cryopreservation media that protects the biological material from damage. In order to be used, the biological material ideally should be thawed in a controlled manner that minimizes damage and desirably brings the material back to a viable state.

Taxus®Express2™: Bypassing By-pass Surgery with Paclitaxel-Coated Stents

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Taxus® Express2™ has the potential to benefit many of the victims of cardiovascular disease, which causes 40% of all deaths in the US. After a heart attack, patients often undergo an invasive by-pass surgery or a less invasive angioplasty procedure to open up the clogged artery. In the latter procedure, a tiny meshlike device called a stent is inserted into the artery to keep it propped open. However, in many of the stent placement cases, the body reacts to this foreign object with scar tissue formation and the artery narrows again.

Vibro-Tactile Stimulation Device and Method for Swallowing Disorder

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The transferred technology is a non-invasive, intensive, swallowing retraining device that combines sensory stimulation with motor retraining to rehabilitate swallow function, initially targeted for dysphagia patients. Dysphagia is a common disorder that creates difficulty swallowing. Patients at risk of choking on fluid or food face a risk of life-threatening aspiration pneumonia and may need to be fed through a tube.

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