Mouse Embryo Culture Chamber and Imaging System and Methods of Use

Description of Technology:

The culture of mouse embryos ex utero and continuous monitoring and imaging of embryos as they develop have applications in drug testing, genetic studies, and basic research on embryonic development. However, the embryo culture systems currently available for post-implantation embryos include rolling bottle culture systems, which do not permit imaging of the developing embryos and do not support the long-term survival and development of embryos ex utero.

Composite Gels and Methods of their Use in Tissue Repair, Drug Delivery, and as Implants

Description of Technology:

Gel materials, particularly hydrogels, typically lose their mechanical strength and stiffness as they swell. This property  limits their use in both biological (e.g., cartilage and ECM repair) and non-biological (e.g., sealant) applications. Innovative materials in both medical and non-medical application areas are sorely needed.

Taxus®Express2™: Bypassing By-pass Surgery with Paclitaxel-Coated Stents

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Taxus® Express2™ has the potential to benefit many of the victims of cardiovascular disease, which causes 40% of all deaths in the US. After a heart attack, patients often undergo an invasive by-pass surgery or a less invasive angioplasty procedure to open up the clogged artery. In the latter procedure, a tiny meshlike device called a stent is inserted into the artery to keep it propped open. However, in many of the stent placement cases, the body reacts to this foreign object with scar tissue formation and the artery narrows again.

Vibro-Tactile Stimulation Device and Method for Swallowing Disorder

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The transferred technology is a non-invasive, intensive, swallowing retraining device that combines sensory stimulation with motor retraining to rehabilitate swallow function, initially targeted for dysphagia patients. Dysphagia is a common disorder that creates difficulty swallowing. Patients at risk of choking on fluid or food face a risk of life-threatening aspiration pneumonia and may need to be fed through a tube.

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