Spatial and Temporal Control of Gene Expression Using a Heat Shock Protein Promoter in Combination with Local Heat

In many instances, it is desirable to express exogenous genes only in certain tissues, and/or at will at certain times, and/or only to a certain degree. However, current gene transfer and exogenous gene expression protocols do not provide adequate means of simultaneously controlling which cells in a heterogeneous population are transformed and when, where, and to what degree the transferred genes are expressed. The invention provides methods for using local heat to control gene expression.

Intranasal or Inhaled Delivery of a Custom IgA Antibody for Protection Against COVID-19

This technology includes an IgA antibody, specifically designed to target the receptor binding domain of SARS-CoV-2, the virus causing COVID-19. Administered intranasally, this antibody has potential neutralizing activity, aiming to prevent COVID-19. IgA, an antibody class present in mucosal areas, plays a crucial role in immune defense at the initial site of viral infection. The primary application of this technology is envisioned as a therapeutic nasal spray, intended to prevent SARS-CoV-2 infection, particularly in high-risk populations.

Computational Alleviation of Depth-dependent Degradation in Fluorescence Images

This technology includes an approach that dramatically lessens the effects of depth-dependent degradation in fluorescence microscopy images. First, we develop realistic ‘forward models’ of the depth dependent degradation and apply these forward models to shallow imaging planes that are expected to be relatively free of such degradation. In doing so, we create synthetic image planes that resemble the degradation found in deeper imaging planes. Second, we train neural networks to remove the effect of such degradation, using the shallow images as ground truth.

Improvement of Axial Resolution via Photoswitching and Standing Wave Illumination

This technology includes an illuminator and reflector that enables flexible standing wave illumination on an inverted microscope stand, and procedures for using such illumination to improve axial resolution in confocal or instant SIM imaging systems. The axial resolution in conventional fluorescence microscopy is typically limited by diffraction to ~700 nm. This method that improves axial resolution ~7-fold over the diffraction limit, and that can be applied to any fluorescence microscope.

Accelerating Multiview Registration and Iterative Deconvolution to Improve Spatial Resolution and Contrast in Fluorescence Microscopy

This technology includes algorithms and software that improve the speed of iterative deconvolution, a common method for improving spatial resolution and contrast in fluorescence microscopy images. These algorithms also improve the registration of multiview datasets, and apply deep learning to accelerate spatially varying deconvolution.

PET Imaging of lntegrin Expression with Suitably Labeled RGD Peptides for Multiple Diagnostic Purposes

This technology includes a number of dimeric RGD peptides which been developed and labeled with various PET isotopes (1BF, 68Ga, and 64Cu) for imaging integrin expression in cancer, inflammation, rheumatoid arthritis, myocardial infarct, stroke and traumatic injury. A number of these peptides have been translated into clinic for diagnosis and therapy response monitoring.

Spatially Selective Fixed-Optics Multicolor Fluorescence Detection System For Microfluidic Device

Available for licensing and commercial development is a new scheme for sensitive spatially resolved and spectrally resolved laser-induced fluorescence detection from multiple microfluidic channels. The prototype instrument has been developed and is versatile in that it contains only fixed optical parts and has simultaneous five-color detection from eight microchannels in a plastic microchip for DNA analysis. The detection scheme could be applied to fluorescence detection for any microchip-based analysis in a transparent substrate.

Image Guided Systems and Methods for Organ Viability Assessment

The number of patients for organ transplants continues to grow, without an increase in the number of organs available for transplant. This has increased interest in transplanting organs from non-traditional sources, such as donations after cardiac death. However, there are currently no methods to objectively measure the effects of resuscitation and ischemia damage on organ viability.

System and Method for Producing Nondiffracting Light Sheets that Improves the Performance of Selective Plane Illumination Microscopy (SPIM)

The technology offered for licensing relates to a system and method of producing nondiffracting beams of light that spatially overlap, but do not interfere with each other when intersecting the detection plane of an optical arrangement. The system includes an illumination source (i.e.
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