Technology ID
TAB-4575

Intranasal or Inhaled Delivery of a Custom IgA Antibody for Protection Against COVID-19

E-Numbers
E-007-2021-0
Lead Inventor
Sadtler, Kaitlyn
Lead IC
NIBIB
Co-Inventors
Memoli, Mathew
ICs
NIBIB
NIAID
Applications
Therapeutics
Therapeutic Areas
Infectious Disease
Development Stages
Pre-Clinical (in vitro)
Research Products
Antibodies

This novel therapeutic technology harnesses the power of custom-engineered IgA antibodies to provide localized protection against COVID-19. Unlike conventional antibody treatments that circulate systemically, this innovation is designed for intranasal or inhaled delivery, placing protection directly at the body’s frontline of defense: the respiratory mucosa. By targeting the receptor binding domain (RBD) of the SARS-CoV-2 virus, the antibody effectively blocks viral entry, offering the potential to halt infection before it begins.

The unique focus on mucosal immunity sets this technology apart, addressing the critical need to neutralize pathogens at their point of entry. Early in vitro testing has already demonstrated high binding affinity to the viral target, underscoring its strong therapeutic promise. This approach not only positions itself as a valuable tool in protecting individuals from infection but also as a means of reducing viral spread within communities.

With its combination of precision targeting, innovative delivery, and preventive impact, this IgA-based therapy represents a breakthrough opportunity in respiratory disease management and a powerful complement to existing vaccines and antibody treatments.

Commercial Applications
The potential application of this technology is the development of a therapeutic nasal spray designed to prevent SARS-CoV-2 infection, with a focus on safeguarding high-risk populations from COVID-19.

Competitive Advantages
The competitive advantage of this technology lies in its specificity, as it targets the receptor binding domain of SARS-CoV-2, increasing its potential to neutralize the virus at its point of entry through intranasal administration. This approach harnesses the protective properties of IgA antibodies, strategically deploying them in mucosal areas to enhance the initial immune defense against COVID-19, particularly benefitting high-risk populations.
Licensing Contact:
Knezevic, Vladimir
vlado.knezevic@nih.gov