Novel In Vitro Granuloma Model for Studying Tuberculosis and Drug Efficacy
Monoclonal Antibodies to the HIV-1 Core Protein p24
Immunoassays and Methods to Diagnose Syphilis by Immobilizing a Lipoidal Antigen on a Solid Support
Improved Protein Quantification Process and Vaccine Quality Control Production
Sensitive Method for Detection and Quantification of Anthrax, Bordetella pertussis, Clostridium difficile, Clostridium botulinum and Other Pathogen-Derived Toxins in Human and Animal Plasma
Improved Botulism, Botulinum Neurotoxin Type-E Diagnostics
Multiplexing Homocysteine in Primary Newborn Screening Assays Using Maleimides as Select Derivatization Agents
An Automated System for Myocardial Perfusion Mapping and Machine Diagnosis to Detect Ischemic Heart Disease with First-pass Perfusion Cardiac Magnetic Resonance Imaging
This technology includes a fully automated computer aided diagnosis system to quantify myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) pixel maps from the first-pass contrast-enhanced cardiac magnetic resonance (CMR) perfusion images. This system performs automated image registration, motion compensation, segmentation, and modeling to extract quantitative features from different myocardial regions of interest.
Anti-Puromycin Antibodies Illuminate the World of Cellular Protein Translation
The Ribopuromycylation (RPM) technology, developed by Dr. Jon Yewdell and Dr. Alexandre David, offers a powerful and universal method for visualizing and studying protein translation within cells. RPM involves the use of puromycin, a molecule that mimics a tyrosyl-tRNA and terminates translation by becoming covalently incorporated into the nascent protein chain's C-terminus within the ribosome's A site. This technique enables the immobilization of puromycylated nascent protein chains on ribosomes when chain elongation inhibitors like cycloheximide or emetine are utilized.