Genes For Niemann-Pick Type C Disease
Specific Inhibition of Gene Expression by Small Double Stranded RNAs
This invention provides for synthetic dsRNAs (20-25 nucleotides in length) and methods that can inhibit gene-specific expression in mammalian cells.
A Mouse Model of Multiple Endocrine Neoplasia, Type I
Clonal Spodoptera Frugiperda Cell lines for Enhanced Expression
This technology includes Spodoptera frugiperda (Sf9) cells which were developed to produce recombinant adeno-associated virus. The cells maintain a copy of the vector genome and for production, require infection with a single baculovirus that expresses either structural and nonstructural proteins to produce rAAV, or the non-structural (Rep) proteins to produce ceDNA.
Mouse Models of Cryopyrin-Associated Periodic Syndrome (CAPS) for Drug Discovery
This technology includes mouse models that express versions of mouse cryopyrin protein containing mutations associated with human CAPS disease. We engineered mutations associated with three specific CAPS phenotypes (familial cold autoinflammatory syndrome (FCAS); Muckle-Wells syndrome (MWS); and neonatal onset multisystem inflammatory disease (NOMID)) into the mouse cryopyrin gene (called Nlrp3) to examine the roles of IL-1 β and related cytokines, and better characterize inflammasome functions.