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This technology includes mycoplasma-free PV (isolated in 1882) and SAD/ERA (isolated in 1935) virus stock for rabies vaccine development. Rabies virus causes a nearly uniformly fatal disease, but can be prevented by timely vaccination. Two of the most common rabies virus vaccine strains are PV and SAD/ERA, both of which have had extensive passaging in both animals and subsequently cultivation in cells. The rabies vaccine virus stocks stored at CDC are heavily contaminated by mycoplasma.

This technology includes an optimized influenza A/H5 subtyping real-time RT-PCR assay for detection and characterization of Asian lineage A/H5N1 viruses. The highly pathogenic avian influenza (HPAI) A/H5N1 viruses, first isolated in human in 1997, have spread among birds over seventy countries on three continents. In 2014 a novel reassortant HPAI A/H5N8 virus has been detected in poultry in Asia, Europe, As well as Canada and USA. In addition, genetic reassortment of this virus with circulating avian influenza viruses has resulted in the novel viral combinations.

This technology includes HIV clones to develop proteomic microarrays for HIV research. The microarray chip can be used to monitor the antibody response to all proteins and many epitopes of HIV-1.

This technology includes a combined IPV and IRV for co-administration and global immunization against polio and rotavirus among children. Currently IPV and IRV are administered by parenteral administration in two separate injections, which complicates routine immunization schedules and is costly.

This technology includes a set of noise controls in the form of structural modifications to the cutting drums used in underground coal mining. Longwall shearer operators are exposed to high levels of noise, i.e., above 98 dB(A), which are clearly well above the permissible exposure level of 90 dB(A). In an effort to reduce this noise exposure, research was conducted that identified the longwall cutting drums as the most significant sound radiating components.

This technology includes systems and methods which allow for a determination of the attenuation and fit of a hearing protection device based on images of a user’s ear. This technology can be used in a wide range of industrial and military settings including but not limited to factories, construction sites, mines, mills, airports, railroads, and military combat training environments.

This technology includes a new concept to develop a bivalent IRV-IPV combination vaccine against rotavirus and polio using a dissolving microneedle patch. Specifically, we describe the formulation for IRV, the fabrication of a microneedle patch for combined IRV-IPV, and the proof of concept for assessing potential interference of immunogenicity and dose sparing in animal studies. Licensed oral rotavirus vaccines, while effective in developed and middle-income countries, are significantly less effective in reducing cases of severe diarrhea among children in developing countries.