A Mouse Model for Type 2 Diabetes
A Mouse Model for Human Osteoarthritis
Mutants Having a Deficit of Functional Steroid Hormone Receptors
Mouse Model and Derived Cells That Hypersecrete Leukemia Inhibitory Factor (LIF)
New Mouse Strain with Conditional Deletion of SMAD7: Analysis of Disease Processes Involving Immunological, Fibrotic or Cardiovascular Indications
T-Cell-Specific Gfi-1 Knockout Mouse
Transgenic Mice with Conditionally-Enhanced Bone Morphogen Protein (BMP) Signaling: A Model for Human Bone Diseases
A Nurr1-Knockout Mouse Model for Parkinson's Disease and Stem Cell Differentiation
Transcription factor Nurr1 is an obligatory factor for neurotransmitter dopamine biosynthesis in ventral midbrain. From a neurological and clinical perspective, it suggests an entirely new mechanism for dopamine depletion in a region where dopamine is known to be involved in Parkinson's disease. Activation of Nurr1 may be therapeutically useful for Parkinson's disease patients; therefore, the mice would be useful in Parkinson's disease research.