Technology ID
TAB-2059

T-Cell-Specific Gfi-1 Knockout Mouse

E-Numbers
E-242-2009-0
Lead Inventor
Zhu, Jinfang (Jeff) (NIAID)
Co-Inventors
Paul, William (NIAID)
Applications
Research Materials
Research Products
Animal Models
Lead IC
NIAID
ICs
NIAID
This is a mouse model available to study T-cell differentiation. Growth factor independent 1 (GFi-1) is a transcriptional repressor that is transiently induced during T-cell activation. This knockout mouse line is a GFi-1[flox/flox] introduced into a mouse Cre controlled by a CD4 promoter, which allows selective removal of GFi-1 exclusively in T-cells. It has thus-far been used to demonstrate that GFi-1 plays a critical role in enhancing Th2 cell expansion and repressing induction of Th17 and CD103+ iTreg cells.
Commercial Applications
  • Tool for studying T-cell proliferation and differentiation.
Licensing Contact:
Prabhu, Yogikala
yogikala.prabhu@nih.gov