The National Eye Institute (NEI) seeks research co-development partners and/or licensees for single-cell RNA sequencing (scRNA-seq) analysis software that leverages existing large language models (LLM) to simplify and enhance data analysis by providing intelligent recommendations and interpretations.
The National Institute of Child Health and Human Development (NICHD) seeks licensees and/or research co-development partners for the development of an injectable contraceptive for women with a pharmaceutical formulation containing levonorgestrel butanoate (LB), a steroidal progestin.
CDC scientists have developed a new design for a multi-well dialysis microplate for equilibrium dialysis. The unique design accommodates a 1:1 buffer to sample ratio and provides additional room at the base of the well to enable optimal cartridge immersion and analyte diffusion. The microplate is readily adaptable into existing automated analytical systems and meets the criteria of American National Standards Institute (ANSI). The microplate is designed for measuring blood or other biological fluid samples over a wide range of sample volumes and may be used in a high throughput manner.
The technology at hand represents a pivotal advancement in the early detection of Type 1 Diabetes (T1D) and the associated autoimmune processes. By utilizing electrochemiluminescence (ECL)-based assays, it enables the precise measurement of diabetes-associated antibodies, particularly Insulin Autoantibodies (IAA) in non-obese diabetic (NOD) mice and anti-insulin antibodies (IA) in individuals with Type 1 diabetes. Notably, these assays are non-radioactive, ensuring safety and compliance, while also offering exceptional reproducibility and efficiency.
The technology involves the development of novel PCSK9 immunogens that are specifically designed to eliminate sequence overlap with human proteins, thereby reducing potential self-reactivity and immunogenicity issues. By selectively grafting epitope residues from non-human PCSK9 or structurally similar sequences onto the epitope-scaffold, these immunogens can induce an immune response against the PCSK9 enzyme without triggering a significant reaction against the body’s own proteins.
Microduplications of the GPR101 gene (located on chromosome Xq26.3 and encodes a G-protein coupled receptor) can result in an excess of growth hormone causing gigantism, that has an onset in early childhood. It is also associated with the growth of sporadic growth hormone producing adenomas in some patients with acromegaly.
NICHD is seeking licensees for development of an adeno-associated viral (AAV) vectors for the treatment of glycogen storage disease type Ia (GSD-Ia).