Non-invasive Pan-Cancer Detection Method
Monoclonal Antibodies Against Bacillus Anthracis Antigens
Preparation of Substituted Diarylpropanamides as RORgt Antagonists for the Treatment of Th17-related Autoimmune Diseases
DNA Methylation Based Non-invasive Blood Diagnostic Assay for Precision Cancer Detection and Classification
Method For Improving Insulin Sensitivity for the Treatment of Diabetes
CNS Therapeutics That Target Neuronal Ceroid-Lipofuscinoses and Thioesterase Deficiency Disorders
Clinically known as Neuronal Ceroid-Lipofuscinoses (NCL), Batten disease, is a rare neuron killing disease and one of the lysosomal storage disorders (LSDs). It is associated with a mutation or lack of palmitoyl-protein thioesterase-1 (PPT1) gene. It manifests very early in a child's life causing absence of brain activity as early as 4 years of age.
Cell Lines Expressing Nuclear and/or Mitochondrial RNAse H1
The National Institute of Child Health & Human Development (NICHD), Program in Genomics of Differentiation, seeks interested parties to further co-develop small molecule inhibitors of RNase H1, especially in regards to genome instability, transcription, and translation.
Enhanced Tumor Reactivity of T Cells Lacking SIT1, LAX1 or TRAT1
Summary:
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is actively seeking potential licensees interested in further developing these inhibitory transmembrane adapter proteins as targets for T-cell immunotherapy for the treatment of cancer, infectious diseases, and autoimmune diseases.