Technology ID
TAB-640

Methods of Inducing Deacetylase Inhibitors to Promote Cell Differentiation and Regeneration

E-Numbers
E-353-2001-0
E-353-2001-1
E-353-2001-2
Co-Inventors
Sartorelli, Vittorio
Applications
Therapeutics
Research Materials
Diagnostics
Therapeutic Areas
Immunology
Lead IC
NIAMS
The present invention discloses a method of enhancing progenitor cell differentiation, including enhancing myogenesis, neurogenesis and hematopoiesis, by contacting a progenitor cell with an effective amount of a deacetylase inhibitor (DI). The progenitor cell can be part of cell culture, such as a cell culture used for in vitro or in vivo analysis of progenitor cell differentiation, or can be part of an organism, such as a human or other mammal. Contacting the progenitor cell with a DI can lead to enhancement of expression of terminal cell-type specific genes in the progenitor cell, such as enhancing expression of muscle-specific genes in myoblasts, and can lead to skeletal muscle hypertrophy. Administering a DI to a subject also can provide some prophylactic or therapeutic effect for inhibiting, preventing, or treating associated with a degeneration or loss of tissue. The DI can be administered to a subject as part of a pharmaceutical composition.
Licensing Contact:
Crooks, Denise
crooksd@mail.nih.gov