The National Eye Institute (NEI) seeks research co-development partners and/or licensees for a thermosensitive, pro-angiogenic material designed for 3D bioprinting.

This technology includes a thermosensitive hydrogel bioink designed for vascular tissue engineering. The hydrogel is unique in that it transitions from a gel state at room temperature to a liquid state at physiological temperatures, allowing for easy handling and application in bioprinting. The primary challenge in tissue engineering is the formation of functional blood vessels, which is critical for tissue viability. Current methods often involve harmful chemical crosslinkers or UV light, which can compromise cell viability. This hydrogel, made from fibrinogen and gelatin, promotes blood vessel formation by providing a supportive extracellular matrix without the use of harmful agents.

The technical solution involves a combination of fibrinogen, which serves as a provisional extracellular matrix, and gelatin, which adjusts viscosity with temperature changes. This innovative approach not only enhances cell viability but also reduces material costs, making it a compelling option for researchers and companies in the field of tissue engineering. You should care about this technology because it represents a significant advancement in bioprinting techniques, enabling the creation of vascularized tissues that closely mimic natural environments.

The licensing opportunity for this technology is open to interested parties looking to collaborate in further development or commercialization. The inventors are seeking partners who can help bring this innovative bioink to market, potentially leading to groundbreaking applications in regenerative medicine and tissue engineering.