Technology ID
TAB-4903

Novel Anti-Idiotype Monoclonal Antibodies for Monitoring Broadly Neutralizing HIV Antibody N6

E-Numbers
E-088-2019-0
Lead Inventor
Mascola, John
Lead IC
NIAID
Co-Inventors
Shi, Wei
Kong, Wing-pui
ICs
NIAID
Applications
Diagnostics
Therapeutic Areas
Infectious Disease
Development Stages
Investigational Device Exemption - Feasibility Study
Research Products
Antibodies

The technology involves the development of two specific anti-idiotype monoclonal antibodies, N6-I and N6-2, which target a broadly neutralizing monoclonal antibody (mAb), N6, known for its effectiveness against HIV. These anti-idiotype antibodies are crucial for detecting and monitoring the N6 mAb's quality and quantity in various settings, including in vivo, in vitro, and in clinical trials.

These antibodies are essential tools for researchers and clinicians working on HIV prevention and treatment strategies. They enable the accurate measurement and tracking of the N6 mAb, which is vital for assessing its efficacy and optimizing its use in therapeutic and preventive interventions. The development of these anti-idiotype antibodies represents a significant advancement in HIV research and could lead to improved strategies for combating the virus.

Commercial Applications
The anti-idiotype monoclonal antibodies, N6-I and N6-2, have diverse applications in HIV research and clinical care. They enable precise monitoring of the broadly neutralizing HIV antibody N6, offering insights into HIV pathogenesis and immune responses. These antibodies are valuable for evaluating new HIV therapies and vaccines, optimizing treatment strategies, and improving patient outcomes. They also have potential applications in the development of novel HIV interventions by assessing immune responses to these treatments.

Competitive Advantages
The competitive advantages of the developed anti-idiotype monoclonal antibodies, N6-I and N6-2, lie in their specificity and utility for monitoring the broadly neutralizing HIV antibody N6. These antibodies offer a precise and reliable method for detecting and quantifying N6 mAb in various biological samples, providing researchers and clinicians with a valuable tool for assessing the efficacy of HIV therapies and vaccines.
Licensing Contact:
Rainwater, Charles
crainwater@mail.nih.gov