Technology ID
TAB-4628
Mycoplasma-free PV and SAD/ERA Virus Stocks for Rabies Vaccine Manufacturing
E-Numbers
E-040-2018-0
Lead Inventor
Wu, Xianfu
Lead IC
CDC
Co-Inventors
Yang, Yong
Olson, Victoria
ICs
CDC
Applications
Vaccines
Research Materials
Therapeutic Areas
Infectious Disease
Development Stages
Pre-Clinical (in vitro)
Research Products
Research Equipment
Plasmids/Vectors
This technology includes mycoplasma-free PV (isolated in 1882) and SAD/ERA (isolated in 1935) virus stock for rabies vaccine development. Rabies virus causes a nearly uniformly fatal disease, but can be prevented by timely vaccination. Two of the most common rabies virus vaccine strains are PV and SAD/ERA, both of which have had extensive passaging in both animals and subsequently cultivation in cells. The rabies vaccine virus stocks stored at CDC are heavily contaminated by mycoplasma.
Commercial Applications
The clean virus seed can be used for rabies vaccine manufacturing.
Competitive Advantages
Mycoplasma contamination is a challenge for the vaccine industry.
Licensing Contact: