Technology ID

A Phospho-specific antibody to Fc “epsilon” R1 “gamma” as a Diagnostic Tool for Allergic Reactions

Lead Inventor
Rivera, Juan (National Inst of Arthritis and Musculoskeletal and Skin Diseases)
Suzuki, Ryo (NIAMS)
Development Stages
Pre-clinical (in vivo)
Lead IC

This technology includes a mouse monoclonal antibody that recognizes the phosphorylated form of the FceRiy which could be used as a diagnostic tool during allergic reactions. The FcERI is central to the activation of mast cells and basophils and activation of this receptor induces these cells to secrete mediators that cause allergic symptoms. This antibody specifically recognizes the phosphorylated tyrosine 47 (Y 47) of the FceRiy. Phosphorylation of this site Indicates that this receptor is in an active state and thus the cells can secrete allergic mediators.

Commercial Applications
This antibody could be used to determine if the FceRI or mast cells or basophils are active at the cellular or tissue level. It has been tested and shown to work for immunoblotting, immunoprecipitation, and immunohistochemistry on cells or tissues from mouse and human. The antibody has also been shown to work for flow cytometry after cell permeabilization.

Competitive Advantages
Only available antibody that can recognize phosphorylation of FceRiy and can therefore be used as a diagnostic agent during allergic reactions.
Licensing Contact:
Knezevic, Vladimir