Technology ID

An Automated System for Myocardial Perfusion Mapping and Machine Diagnosis to Detect Ischemic Heart Disease with First-pass Perfusion Cardiac Magnetic Resonance Imaging

Lead Inventor
Hsu, Li-Yueh (NHLBI)
Arai, Andrew (National Heart, Lung and Blood Institute (NHLBI/NIH))
Jacobs, Matthew (NHLBI)
Benovoy, Mitchel (Circle Cardiovascular Imaging Inc)
Software / Apps
Therapeutic Areas
Development Stages
Pre-clinical (in vivo)
Research Products
Research Equipment
Computational models/software
Lead IC

This technology includes a fully automated computer aided diagnosis system to quantify myocardial blood flow (MBF) and myocardial perfusion reserve (MPR) pixel maps from the first-pass contrast-enhanced cardiac magnetic resonance (CMR) perfusion images. This system performs automated image registration, motion compensation, segmentation, and modeling to extract quantitative features from different myocardial regions of interest. It then performs automated classification to detect potential lesions in the myocardium and generates analysis reports to summarize global and regional myocardial perfusion, possible myocardial sectors/territories and coronary arteries that may be diseased to assist physicians in clinical decision making.

Commercial Applications
This will be the first of its kind system to generate MBF and MPR maps, detect cardiac lesion, and generate a machine diagnostic report from CMR perfusion fully automatically.

Competitive Advantages
Current similar system still requires manual segmentation of the myocardium on the pixel maps to depict different coronary distributions; this fully automated system contains important features beyond prior technology as a computer- aided diagnosis system to assist physician to make
Licensing Contact:
Shmilovich, Michael