Technology ID

Device for Closure of Transvascular or Transcameral Access Ports

Lead Inventor
Lederman, Robert (NHLBI)
Rogers, Toby (Med Star Washington Hospital Center)
Rafiee, Nasser (Mehr Medical)
Medical Devices
Therapeutic Areas
Development Stages
Pre-clinical (in vivo)
Research Products
Research Equipment
Lead IC

This technology includes a novel method to access the arterial circulation to allow introduction of large devices, such as transcatheter aortic valve replacement, percutaneous left ventricular assist devices, and thoracic aortic endografts. It also can be used in most labeled and off-label applications of Amplatzer nitinol occluder devices to occlude intracardiac holes and to allow non-surgical direct access to the heart. This new disclosure adds additional design features that have been tested in vivo. These include a new compression member design that enhances wall apposition and hemostasis, a new delivery cable design, alternative endoluminal limb designs. The new design allows flexible deliver and recovery but is designed to avoid inadvertent pull-through. The disclosed invention has already been built and reduced to practice in an animal model.

Commercial Applications
Method and device to access arterial circulation to allow introduction of devices in various cardiac procedures.

Competitive Advantages
The unique features of the device which are not available in commercial devices marketed for the occlusion of congenital heart and vascular defects include:
  • New compression member design that enforces flattening of the nitinol endoluminal disks
  • Wing-shaped endoluminal disks to enhance disk stiffness
  • Flexible delivery cable that still allows continuous central guidewire access
  • Beveled marker sheath catheter design to accommodate oblique delivery angles
Licensing Contact:
Mistry, Pragnesh