Dold, George (NIMH)
Kim, Junghee (National Institute of Mental Health (NIMH))
Lisanby, Sarah (National Institute of Mental Health (NIMH))
Pritchard, Bruce (National Institute of Mental Health (NIH/NIMH))
Schor, Robert (NIMH)
The Multichannel Individualized Stimulation Therapy (MIST) device is a multichannel electrical stimulation system that can be used for targeted, individualized electroconvulsive therapy (ECT), especially for treatment-resistant depression (TRD). Millions of individuals suffer from TRD, for which ECT is often the most efficacious and rapidly acting treatment option.
Present clinical ECT devices use a single-channel to deliver strong electric fields broadly distributed throughout brain, producing significant memory loss and variability in clinical outcomes. These challenges result in the underutilization of this highly effective treatment. MIST is the first multichannel ECT device to address these limitations by delivering flexible and multi- focal stimulation, which has the potential to maximize clinical efficacy and minimize side effects. Thus, the technology represents a much more desirable method for delivering seizure therapy for those suffering from severe depression, which affects over 280 million people worldwide, and other serious disorders.