Technology ID
TAB-4330
Anti-Viral Polypeptide Griffithsin: Compounds, Compositions, and Methods of Use
E-Numbers
E-025-2006-0
Lead Inventor
O'Keefe, Barry (NCI)
Co-Inventors
McMahon, James (NCI)
Mori, Toshiyuki (NCI)
Applications
Therapeutics
Therapeutic Areas
Infectious Disease
Development Stages
Discovery
ICs
NCI
This technology describes additional methods of using the griffithsin anti-viral polypeptides described in related NCI invention (reference number E-106-2003). Specifically, this invention describes the use of GRFT to inhibit viral infection of hepatitis C viral infection, a severe acute respiratory syndrome (SARS) viral infection, an H5N1 viral infection, or an Ebola viral infection.
Issued patents: US 8,088,729 (Jan. 3, 2012) and foreign rights in France, Germany, Ireland, United Kingdom, Switzerland (all granted)
Competitive Advantages:
- Highly Potent Broad-Spectrum Antiviral Lectin
- Superior in vitro and in vivo antiviral activity with minimum host toxicity against a variety of clinically relevant, enveloped viruses.
Commercial Applications:
- Microbicide that can prevent viral transmission
- Therapeutic against enveloped virus-mediated diseases
Licensing Contact: