This technology includes a clinical diagnostic tool for measuring vitamin C elimination by human kidneys that can be used for detecting, monitoring, and managing acute and chronic diseases. Findings revealed significant associations between vitamin C renal leak status and clinical variables affecting renal function and blood glucose. The technology uses vitamin C depletion-repletion kinetics and pharmacokinetic models to establish a physiological vitamin C renal threshold. This allowed us to define “vitamin C renal leak” as urinary vitamin C levels below the established minimal elimination threshold. The technology was tested and validated in multiple clinical studies involving more than five cohorts of healthy controls or those with chronic disease.
Characterization of vitamin C renal leak may be used in the prevention, screening, diagnosis, treatment, or management of many diseases. For various acute or chronic medical conditions, vitamin C renal leak status may be the earliest indicator of underlying pathogenesis when compared to current laboratory measures such as creatinine or proteinuria. Vitamin C renal leak can also potentially be used to monitor disease progression (staging) and for positive responses or adverse reactions to therapeutic interventions (drugs or procedures). Additionally, knowledge of vitamin C renal leak status in individual patients or its prevalence in disease states may provide guidelines and recommendations for daily intake.