Influenza A and B viruses can cause seasonal flu epidemics ― commonly known as the “flu season” ― and infect the nose, throat, eyes, and lungs in humans. Typically, flu seasons that are dominated by influenza A (H3N2) virus activity have higher associated hospitalizations and deaths in at-risk groups, such as people ages 65 and older and young children. Influenza A (H3N2) virus can also cause respiratory disease in animals, such as canines and swine.
CDC discovered a series of 17 hybridomas (murine B cell fused with an immortal myeloma that produces a specific monoclonal antibody (mAb)) that recognize neuraminidase (N2) from influenza A (H3N2) viruses. Researchers identified the hybridomas of murine origin with mAbs that recognize N2 from influenza A/Hong Kong/4801/2014. The technology has potential utility in diagnostic assays, surveillance, prophylaxis, therapeutic treatments, and research reagents. Additional testing is planned to better understand the technology’s activities and potential.