Technology ID

Trans-auricular Left Atrial Appendage Ligation to Prevent Thrombosis

Lead Inventor
Kocaturk, Ozgur (NHLBI)
Ratnayaka, Kanishka (NHLBI)
Lederman, Robert (NHLBI)
Rogers, Toby (NHLBI)
Non-Medical Devices
Medical Devices
Consumer Products
Therapeutic Areas
Lead IC
This technology includes an interventional device to occlude the left atrial appendage to prevent thrombus formation. Atrial fibrillation is the most common cardiac arrhythmia and is associated with formation of thrombus in the left atrial appendage. Standard preventative treatment involves anticoagulation, which is not tolerated by all patients. Existing devices necessitate improvement because they need trans-septal puncture and anticoagulation to prevent thrombus or are prone to life-threatening complications. All existing devices can cause left atrial appendage perforation leading to cardiac tamponade, requiring urgent intervention. This device is designed to ligate and exclude the left atrial appendage from the left atrial cavity within the pericardial space. The left atrial appendage is then grasped with one limb of the device. The second limb deploys a suture and, using counter-traction between the two limbs, the suture is delivered to the base or neck of the left atrial appendage where it is tightened and secured. The suture is then cut, and the right atrial appendage puncture is sealed.
Commercial Applications
Cardiac device to prevent thrombus formation.

Competitive Advantages
The unique features of the device are:
  • Two coaxial limbs with different purposes
  • Application via a trans-auricular route
  • An atraumatic grasper for the left atrial appendage
  • A coaxial suture delivery system resembling the TRAIPTA device recently disclosed
  • Counter traction between the two limbs allows complete external encirclement of the left atrial appendage at its ostium without risking appendage perforation rupture or avulsion
Licensing Contact:
Mistry, Pragnesh