Nagasaki, Atsuhiro (NIAMS)
Foster, Brian (Ohio State University)
Millan, Jose (Sanford Burnham Prebys Medical Discovery Institute)
Samara, Nadine (NIDCR)
This technology includes a product for local delivery of alkaline phosphatase for the treatment of periodontal disease. Our laboratory has discovered that factors regulating phosphate metabolism and specifically the appropriate balance between phosphate (Pi) and pyrophosphate (PPi) at local sites are needed for formation (development), maintenance and regeneration of the tooth root surface (cementum), periodontal ligament (PDL) and surrounding alveolar bone, i.e., the periodontal apparatus. Furthermore, we have shown in alkaline phosphatase knock out mice that targeting alkaline phosphatase to mineralized tissues promotes formation and regeneration of the periodontal apparatus.
Product for use as a local delivery to treat periodontal disease, to form new bone at local sites in preparation for implants and other dental appliances and to treat peri-implantitis.
- Less difficulty in the purification of the protein
- Suitable for local delivery to the oral cavity
- Tailored toward regeneration of tissues, not just formation