This technology includes a transgenic allele for a mouse knockout model for the KCNN4 gene. Secretion of fluids from these salivary glands requires the coordination of multiple water and ion channel proteins. Notably, the majority of these channels have been shown to be up-regulated by increased calcium concentrations. The relevant calcium-activated potassium channels are split into the small, intermediate, and large conductance channels (called the SK, IK, and BK channels). The KCNN4 gene plays a part in the IK and BK channels. The mouse knockout model described in this technology is the only model for the KCNN4 gene. The animal is only available from JAX (https://www.jax.org/strain/018826).
This is the only mouse knockout model for the KCNN4 gene.