Dummer, Patrick (NIDDK)
Pisitkun, Trairak (NHLBI)
This technology includes antibodies to apolipoprotein L1 (ApoL 1) to be used in basic science laboratory studies. ApoL 1 is a protein that is present within cells and circulates as component of high-density lipoprotein. Its functions are not well understood. Recently APOL 1 genetic variants have been shown to be highly associated with kidney disease in African Americans.
Utilization in basic science laboratory work: Immunostaining of cells or tissue, Western blotting, immunoprecipitation, possibly a capture ELISA.
- K5 antibody: peptide in N terminal portion is unique in that there are no commercially available ApoL 1 N terminal antibodies with an epitope that does not overlap the signaling peptide.
- K9 antibody: peptide in C terminal portion is peptide selected is unique in that it that does not overlap the ApoL 1 kidney-disease risk mutations.