Technology ID

Transgenic mice useful for study of gonadotropin-releasing hormone (GnRH) and a GnRH-secreting neuronal cell line (GN cell line)

Lead Inventor
Wray, Susan (National Institute of Neurological Disorders and Stroke)
Radovick, Sally (Rutgers The State University of New Jersey)
Weintraub, Bruce (Trophogen)
Wondisford, Fredric (Rutgers The State University of New Jersey)
Research Materials
Therapeutic Areas
Lead IC
This technology involves the generation and use of a mouse model for studying hypogonadism in humans and a cell line to study cellular and molecular properties of gonadotropin-releasing hormone (GnRH) cells. The mouse model expresses the simian virus 40 T antigen driven by the GnRH promoter, resulting in hypogonadism due to an arrest in neuronal migration during development and tumor formation along the migratory pathway. Olfactory bulb tumors in this model animal were dispersed, and GnRH-secreting neuronal cell line (GN/NLT cell line) was established.
Commercial Applications
Animal model or cell line could be sold by research reagent companies for research use purposes. Cell lines are models for: 1) identifying genes and cellular mechanisms influencing maturation of neuronal phenotype, 2) delineating mechanisms and genes underlying neuronal migration and 3) factors which influence neuronal movement.

Competitive Advantages
The mouse and cell line provide a novel method to study the gonadotropin-release hormone pathway.
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