Radovick, Sally (Rutgers The State University of New Jersey)
Weintraub, Bruce (Trophogen)
Wondisford, Fredric (Rutgers The State University of New Jersey)
This technology involves the generation and use of a mouse model for studying hypogonadism in humans and a cell line to study cellular and molecular properties of gonadotropin-releasing hormone (GnRH) cells. The mouse model expresses the simian virus 40 T antigen driven by the GnRH promoter, resulting in hypogonadism due to an arrest in neuronal migration during development and tumor formation along the migratory pathway. Olfactory bulb tumors in this model animal were dispersed, and GnRH-secreting neuronal cell line (GN/NLT cell line) was established.
Animal model or cell line could be sold by research reagent companies for research use purposes. Cell lines are models for: 1) identifying genes and cellular mechanisms influencing maturation of neuronal phenotype, 2) delineating mechanisms and genes underlying neuronal migration and 3) factors which influence neuronal movement.
The mouse and cell line provide a novel method to study the gonadotropin-release hormone pathway.