Technology ID

Signal Transduction Inhibitors Of Allergic Reactions

Vonakis, Becky
Metzger, Henry
Research Materials
Therapeutic Areas
Lead IC
Allergic reactions affect nearly 40 million persons in the United States. Allergic reactions are due to a sequential interaction beginning with the extracellular aggregation of the high affinity receptor for IgE (FcepsilonRI) followed by intracellular tyrosine phosphorylation which initiates a further cascade of events eventually leading to histamine and cytokine release. The reaction is initiated by Lyn kinase which is pre-associated with the FcepsilonRI. It was shown that the introduction of a unique portion of the N-terminal region of Lyn A kinase into cells inhibits the receptor tyrosine phosphorylation in a dose and time-dependent manner. Without receptor phosphorylation, allergic reactions can not occur. The NIH is looking for a company to license and independently develop the technology or to work in collaboration with the NIH scientists via a Cooperative Research and Development Agreement to further research and develop the allergy treatment. It is believed that this technology may ultimately lead to an anti-allergy drug or allergy therapy.
Licensing Contact:
Specialist (ALS), Admin. Licensing