Technology ID

A method to label heparan sulfate proteoglycan in the plasma membrane of mammalian cells

Lead Inventor
Ye, Yihong (NIDDK)
Zhang, Qi (NIDDK)
Research Materials
Lead IC
Heparan sulfate proteoglycan (HSPG) is a group of lipid-anchored proteoglycans, engaged in a variety of key biological functions on cell surface. HSPG-mediated endocytosis of neurotoxic protein aggregates has been linked to aging related neurodegenerative diseases. Labeling HSPG is a promising technique to trace cell profile in cell research, monitor its trafficking in live cells and in tissues. Researchers at the NIDDK have discovered a method in which a positively charged fluorescent protein binds specifically to HSPG on cell surface. This is a promising cost-effective technique that will help scientists to monitor the fate of HSPG in real time on live cell surface as well as to rapidly label the cell boundary-frequently required in cell biology research.
Commercial Applications
  • This technology will be useful to the researchers working on HSPG function in mammalian cells
  • This technology will benefit cell biologists in general to quickly label the cell boundary while doing cell imaging
  • This technology will be useful to researchers working in the field of aging related neurodegenerative studies
Competitive Advantages
  • This technology allows a rapid way to detect HSPG on cell surface in live cells
  • This is a faster and more cost effective technology which can also be used in live cell imaging to track HSPG-dependent endocytosis of cargo proteins compared to the current practices which use HSPG antibodies to label HSPG
  • This technology offers a quick method to label the cell boundary-often required in cell biology research
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