IRF8, a member of interferon regulatory factor (IRF) family of transcription factors is a novel intrinsic transcriptional inhibitor of TH17-cell differentiation. TH17-cells are believed to be involved in the pathogenesis of various autoimmune/inflammatory diseases.
These materials could be used to help define patterns of gene expression important for the development and function of cells including possible contributions to understanding: normal immune responses, inflammatory conditions, autoimmunity and anti-viral responses.
- Target identification in B and T cell deficiency, macrophage defects and hematopoiesis
- A tool for investigating IRF8 mediated issues associated with inflammation and autoimmunity
- Investigative tool for development of potential therapeutics for lymphoma and Human Chronic Myeloid Leukemia
- Mice with established germ line transmission for use in conditional deletion of the IRF8 gene in any cellt type