Technology ID

Floxed Targeted Mouse Strain for Use in Conditional Deletion of the Irf8 Gene

Lead Inventor
Morse, Herbert (NIAID)
Research Materials
Lead IC
IRF8, a member of interferon regulatory factor (IRF) family of transcription factors is a novel intrinsic transcriptional inhibitor of TH17-cell differentiation. TH17-cells are believed to be involved in the pathogenesis of various autoimmune/inflammatory diseases. These materials could be used to help define patterns of gene expression important for the development and function of cells including possible contributions to understanding: normal immune responses, inflammatory conditions, autoimmunity and anti-viral responses.
Commercial Applications
  • Target identification in B and T cell deficiency, macrophage defects and hematopoiesis
  • A tool for investigating IRF8 mediated issues associated with inflammation and autoimmunity
  • Investigative tool for development of potential therapeutics for lymphoma and Human Chronic Myeloid Leukemia
Competitive Advantages
  • Mice with established germ line transmission for use in conditional deletion of the IRF8 gene in any cellt type
Licensing Contact:
Taylor-Mulneix, Dawn