Technology ID

Fusion Glycoprotein Vaccine for Human Metapneumovirus

Lead Inventor
Kwong, Peter (NIAID)
Joyce, Michael (NIAID)
Collins, Peter (NIAID)
Buchholz, Ursula (NIAID)
Stewart-Jones, Guillaume (NIAID)
Zhang, Baoshan (NIAID)
Yang, Yongping (NIAID)
Corti, Davide (Institute for Research in Biomedicine (IRB))
Lanzavecchia, Antonio (Institute for Research in Biomedicine (IRB))
Therapeutic Areas
Infectious Disease
Lead IC
Human metapneumovirus (hMPV), a negative, single-stranded RNA virus, accounts for approximately 5-15% of infant respiratory tract infections and poses a severe risk of disease and hospitalization in both the elderly and the immunocompromised. Investigators at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID) have generated an hMPV fusion glycoprotein (“F protein”) stabilized in a prefusion conformation.

Stabilizing this prefusion conformation of the F protein reveals an immunodominant site which makes it an ideal vaccine immunogen. The prefusion stabilized F protein immunogen can be delivered as either an isolated homotrimer or trimers displayed on a nanoparticle. These immunogens elicit broad and potent hMPV-neutralizing antibodies.

This technology is available for licensing for commercial development in accordance with 35 U.S.C. § 209 and 37 CFR Part 404.
Commercial Applications
  • Vaccine for prevention of human metapneumovirus infection
Vaccine for prevention of human metapneumovirus infection
Competitive Advantages
  • No human metapneumovirus vaccine is currently available
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