Technology ID

Novel Magnetic Resonance Spectroscopy (MRS) Technique to Quantify Brain Metabolites

Lead Inventor
Li, Linqing (NIMH)
Shen, Jun (NIMH)
Software / Apps
Research Materials
Non-Medical Devices
Medical Devices
Therapeutic Areas
Psychiatry/Mental Health
Development Stages
Pre-Clinical (in vitro)
Lead IC
With respect to quantification of metabolites in the brain, conventional methods of magnetic resonance spectroscopy (MRS) yield results that are highly variable and highly dependent on the sequence type being applied. This invention describes a novel MRS technique that involves preparing longitudinal steady states at different flip angles using trains of RF pulses interspersed with field gradients to quantify metabolites. The method allows quantification of metabolites and their relaxation rates under specified parameters, which may create new ways of analyzing and interpreting tissue properties or identifying and characterizing diseases of the human brain, including epilepsy, multiple sclerosis, stroke, cancer, and psychiatric diseases. In addition, due to the linear feature (equation), the quantification of metabolites and their relaxation rates in the brain can be achieved several times faster than conventional techniques, especially for quantification of glutamate (neuronexcitatory) and lactate (important cancer and stroke biomarker).
Commercial Applications
  • Non-invasive MRS diagnostic imaging
Competitive Advantages
  • Ability to measure metabolite relaxation under specific parameters
  • Allows fast quantification of glutamate (neuroexcitatory) and lactate (cancer and stroke biomarkers)
  • Can be optimized to eliminate baseline interference from overlapping metabolite signals
  • Minimizes diffusion effect associated with physiological movement
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