Technology ID
TAB-2955
WNT1-Induced Secreted Protein-1 Knockout Mouse Model
E-Numbers
E-234-2015-0
Lead Inventor
Young, Marian
Lead IC
NIDCR
Co-Inventors
Maeda, Azusa
Ono, Mitsuaki
ICs
NIDCR
Applications
Therapeutics
Research Materials
Diagnostics
Therapeutic Areas
Ophthalmology
Oncology
Infectious Disease
Immunology
Geriatrics
Endocrinology
Dental
Cardiology
Development Stages
Pre-Clinical (in vitro)
Development Status
In vivo data available (animal)
WNT1-induced secreted protein-1 (WISP1) is expressed at high levels in osteoblasts and their precursors. WIPS1 plays an important role in various aspects of bone formation. Scientists at the NIH generated Wisp1-deficient (Wisp1-/-) mice. Deletion of Wisp1 resulted in a decrease in bone mineral density, total bone volume, bone thickness, and biomechanical strength. Wisp1 knockout mouse model can be used to study the molecular mechanisms of bone turnover and patho/physiology of tissues that express WISP1. The animal is only available from MMRRC.
Commercial Applications
- To study the molecular mechanisms of bone formation and osteodifferentiation.
- To study the patho/physiology of tissues that express WISP1, including cartilage during osteoarthritis, healing skin, and other soft tissues including lung, pancreas, and heart.
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