Technology ID

Human Rotavirus Strains and Vaccines for Neonatal Childhood Protection

Lead Inventor
Jiang, Baoming (CDC)
Glass, Roger (CDC)
Wang, Yuhuan (CDC)
Gentsch, Jon (CDC)
Research Materials
Consumer Products
Therapeutic Areas
Infectious Disease
Development Stages
Pre-Clinical (in vitro)
Development Status
  • In vitro data available
  • In vivo data available (animal)
Research Products
Research Equipment
Lead IC
This invention relates to rotavirus vaccine compositions and methods of vaccination. Rotaviral infection is the most commonly occurring gastrointestinal illness of children world, affecting both developed and developing economies. Additionally, rotavirus infections can affect livestock (especially calves and piglets), and resulting mortality/morbidity cause major economic losses for farmers and nations each year.

The vaccine strains include Rotavirus A CDC-9 (P[4]Gl) and CDC-66 (P[4]G2 serotype). These strains represent common rotavirus serotypes and may serve as improvements or alternatives to current live, oral rotavirus vaccine strains. Further, this technology has demonstrated efficacy in a large animal (piglets) modeling.
Commercial Applications
  • Novel rotavirus vaccines
  • Neonatal/childhood vaccination initiatives
  • Rotavirus surveillance programs, important for both developing and developed nations
Competitive Advantages
  • Isolated strains are representative of those involved in community-acquired infection
  • Suitable for the development of improved, broadly effective rotavirus vaccines
  • Can be developed for injection and/or oral vaccine administration
  • Derived vaccines may be administered alone or in combination with other vaccines
Licensing Contact:
Motley, Jonathan