Technology ID

Recombinant NIE Antigen from Strongyloides stercoralis

Lead Inventor
Nutman, Thomas (NIAID)
Varatharajalu, Ravi (George Washington University)
Neva, Franklin (NIAID)
Research Materials
Therapeutic Areas
Infectious Disease
Development Status
  • Prototype
  • Pilot
  • Pre-clinical
  • In vitro data available
  • In vivo data available (human)
Strongyloides stercoralis is an intestinal nematode endemic that affects an estimated 30 to 100 million people worldwide. Many of these individuals may be asymptomatic for decades. The present invention discloses a NIE recombinant antigen that can be used in improved assays and diagnostics for S. stercoralis infection. The NIE antigen is the only one that is non-cross-reactive with sera from humans with other related filaria infections. The NIE antigen can be utilized as a skin test antigen for immediate hypersensitivity as well as for use in ELISA or other assays.
Commercial Applications
  • Assays and diagnostics for S. stercoralis infection
Competitive Advantages
  • Only non-cross-reactive Strongyloides antigen
  • Use in a variety of formats
Licensing Contact:
Mattes, Theodoric