Varatharajalu, Ravi (George Washington University)
Neva, Franklin (NIAID)
- In vitro data available
- In vivo data available (human)
Strongyloides stercoralis is an intestinal nematode endemic that affects an estimated 30 to 100 million people worldwide. Many of these individuals may be asymptomatic for decades. The present invention discloses a NIE recombinant antigen that can be used in improved assays and diagnostics for S. stercoralis infection. The NIE antigen is the only one that is non-cross-reactive with sera from humans with other related filaria infections. The NIE antigen can be utilized as a skin test antigen for immediate hypersensitivity as well as for use in ELISA or other assays.
- Assays and diagnostics for S. stercoralis infection
- Only non-cross-reactive Strongyloides antigen
- Use in a variety of formats