Technology ID

Novel Recombinant Rabies Vaccine Also Capable of Immunocontraception

Lead Inventor
Wu, Xianfu (CDC)
Rupprecht, Charles (CDC)
Therapeutic Areas
Infectious Disease
Development Status
  • Pre-clinical
  • In vitro data available
  • In vivo data available (animal)
This invention relates to a recombinant, attenuated rabies vaccine that is also capable of inhibiting reproductive fertility. An Evelyn-Rokitnicki-Abelseth (ERA) rabies vaccine backbone, combined with a reproductive-specific protein, such as gonadotropin-releasing hormone (GnRH) or the sperm-binding zona-pellucida-glycoprotein-3 (ZP3) receptor, allows reduction in both rabies transmission and uncontrolled reproduction in stray animals. The ERA rabies vaccine backbone has previously shown strong efficacy in animal studies. This vaccine may be delivered via injection or orally, including in an animal's food.
Commercial Applications
  • Development of rabies and immunocontraceptive vaccines
  • Immunogenic compositions for both prevention and treatment of rabies virus
  • Animal welfare initiatives and rabies vaccination programs
Competitive Advantages
  • Live, attenuated rabies vaccines show greater efficacy than older, inactivated rabies vaccine in prior animal studies
  • Potential for oral delivery, enabling vaccination of feral and difficult-to-reach animal populations
  • Novel approach to simultaneously addressing rabies transmission and uncontrolled wild animal reproduction
Licensing Contact:
Mitzelfelt, Jeremiah