Technology ID

Real-Time PCR for Detecting Legionella Species and Discriminating Legionella pneumophila

Lead Inventor
Benson, Robert (CDC)
Holloway, Brian (CDC)
McCaustland, Karen (CDC)
Yang, Patrick (CDC)
Therapeutic Areas
Infectious Disease
Development Status
  • Early-stage
  • In vitro data available
Legionella pneumophila is the causative species in most cases of Legionnaires' disease (LD). CDC scientists have developed a real-time PCR assay capable of detecting all Legionella species and discriminating L. pneumophila from other Legionella species. LD is typically difficult to diagnose from a clinical standpoint as it confers no unique clinical features or symptoms. This assay provides a rapid and accurate alternative to laborious PCR assays, prone to aberrant results. It provides a sensitive alternative for diagnosis of Legionnaires' disease and detection of L. pneumophila.
Commercial Applications
  • Diagnostic for Legionnaires’ disease
  • Detection of all Legionella species and specific discrimination of L. pneumophila
Competitive Advantages
  • Faster than immunoassays
  • Less laborious than current LD diagnostics
  • Rapid, sensitive, and specific
  • Curtails misdiagnoses associated with serological evaluations
  • Easily adaptable to kit form
Licensing Contact:
Motley, Jonathan
Phone: 301-496-2644