Technology ID

Intra-bone Drug Delivery Device and Method

Lead Inventor
Pantin, Jeremy (NHLBI)
Hoyt, Robert (NHLBI)
Hunt, Timothy (NHLBI)
Clevenger, Randall (NHLBI)
Aras, Omer (Clinical Center (CC))
Childs, Richard (NHLBI)
Development Status
  • In vitro data available
  • Prototype
The invention pertains to devices for directly infusing cellular therapeutics into patient bone. The device monitors intra-bone pressure using pressure sensors disposed at its proximal end and adjusts infusion pressures during infusion such that intra-bone pressure does not exceed levels of systemic blood pressure. Such devices, apparatus and methods are particularly suitable for use in performing bone marrow transplants, particularly transplants that utilize cord blood as a stem cell source.
Commercial Applications
  • Drug delivery to bones
Competitive Advantages
  • Therapeutic uptake efficiency
  • Drug delivery efficiency
  • Target specificity
Licensing Contact:
Shmilovich, Michael
Phone: 301-435-5019