Technology ID
TAB-2475

Image Analysis Software for Quantitative Evaluation of Striation Patterns and their Defects in Skeletal Muscles

E-Numbers
E-264-2012-0
Lead Inventor
Liu, Wenhua (NIAMS)
Co-Inventors
Ralston, Evelyn (NIAMS)
Development Status
Prototype
Lead IC
NIAMS
ICs
NIAMS
Available for licensing is software written in MatLab for evaluating striation patters in images of skeletal muscle fibers for better sensitivity in the quantitation of skeletal muscle disorders. Skeletal muscles have a regular, periodic organization (the periodicity of the sarcomeres), which is not only structural but also functional. Muscle pathologies create disorder in the normally periodic myofibrils. Objective grading of muscle morphology is necessary to assess muscle health, compare biopsies, and evaluate treatments and the evolution of disease.
Commercial Applications
Drug development for muscular disorders.

Competitive Advantages
Automated analysis of sarcomere dysplasia for objective grading of muscle morphology.
Licensing Contact:
Shmilovich, Michael
shmilovm@nih.gov
Phone: 301-435-5019