Technology ID
TAB-2467

Polyclonal Antibodies for the Specialized Signaling G protein, Gbeta5

E-Numbers
E-192-2006-0
Lead Inventor
Simonds, William (NIDDK)
Co-Inventors
Zhang, Jianhua (NIDDK)
Development Status
In vitro data available
Lead IC
NIDDK
ICs
NIDDK
Researchers at NIDDK have developed polyclonal antibodies against the G protein, Gbeta5. Gbeta5 is a unique and highly specialized G protein that exhibits much less homology than other Gbeta isoforms (~50%) and is preferentially expressed in brain and neuroendocrine tissue. It is expressed prominently in the neuronal cell membrane, as well as in the cytosol and nucleus. Although this distribution pattern suggests that Gbeta5 may shuttle information between classical G protein-signaling elements at the plasma membrane and the cell interior, its function in the brain is largely unknown.

The antibodies were separately generated in rabbits to KLH-conjugates of peptides from the N-terminus of Gbeta5 (antibody ATDG) and the C-terminus of Gbeta5 (antibody SGS). The antibodies can be used for immunoblotting (ATDG, SGS), and immunoprecipitation (ATDG). They can be used to facilitate our understanding of the unique biology and function of Gbeta5 in brain and neurons.
Commercial Applications
These antibodies can be used for research purposes (immunoblotting, immunoprecipitation) by those studying the biology and function of Gbeta5.

Competitive Advantages
Very specific antibodies to study Gbeta5 and G protein signaling.
Licensing Contact:
Tong, Betty
tongb@niddk.nih.gov
Phone: 301-451-7836