Technology ID

New Mouse Strain with Conditional Deletion of SMAD7: Analysis of Disease Processes Involving Immunological, Fibrotic or Cardiovascular Indications

Lead Inventor
Diaz, Marilyn (NIEHS)
Research Materials
Research Products
Animal Models
Lead IC
SMAD7 conditional knockout mice are available for licensing. SMAD7 can be knocked out by breeding with CRE-recombinase transgenic mice with a variety of promoters to yield tissue or cell type-specific deletions of SMAD7. SMAD7 has been shown to play a role in bone morphogenesis, cardiovascular tissue generation, immune regulation and fibrosis. Therefore, these mice provide a unique model to examine the role of the SMAD7 gene in disease processes that involve immunological, fibrotic, or cardiovascular components. Specifically, these mice may represent a novel model of Scleroderma, a disease with both an immunological and fibrotic component.
Commercial Applications
  • Mouse model of Scleroderma
  • Means of studying bone morphogenesis and cardiovascular tissue generation
  • Means of studying the role of SMAD7 in immune regulation
Licensing Contact:
Choudhry, Vidita
Phone: 301-594-4095