Technology ID
TAB-2049

Device for Selective Partitioning of Frozen Cellular Products

E-Numbers
E-173-2009-0
Lead Inventor
Childs, Richard (NHLBI)
Co-Inventors
Vasu, Sumithira (Clinical Center (CC))
Applications
Therapeutics
Research Materials
Non-Medical Devices
Medical Devices
Diagnostics
Consumer Products
Therapeutic Areas
Ophthalmology
Oncology
Neurology
Infectious Disease
Endocrinology
Dental
Cardiology
Development Stages
Prototype
Development Status
Prototype
Lead IC
NHLBI
ICs
NHLBI
Cryopreservation using liquid nitrogen frozen polyvinyl bags allows for storing cellular materials for extended periods while maintaining their activity and viability. Such bags are commonly used in the clinic to store blood products including blood cells, plasma, hematopoietic stem cells, umbilical cord blood for future uses including transplantation. These materials, typically obtained in limited quantities, may be of great therapeutic value, as is the case of stem cells or cord blood derived cells which can be used to potentially treat a number of diseases. Currently, even if only a small portion of the cryopreserved sample is needed the whole bag must be thawed, wasting much of the sample or rendering the remaining sample susceptible to contamination since it cannot be effectively refrozen or sterilized. The present device meets an unmet need for retrieving a portion of a frozen sample stored in polyvinyl cryopreserved bags, resealing the remainder of the sample and preserving the cryopreserved state and integrity of the rest of the cellular product without compromising viability and sterility.
Commercial Applications
  • Partitioning cryopreserved cell products
  • Maintenance of sterility of partitioned product
  • Maintenance of viability of partitioned product
  • Resealing of cryopreservation bag
  • Multiple use of patient derived cellular products
Competitive Advantages
  • Cryopreservation
  • Cellular Products
  • Hematopoietic stem cells
  • Umbilical cord blood
  • iPSCs
  • Transplantation
  • Chronic spinal cord injury
  • Neurological disorders
  • Cancer immunotherapy
  • Cell banking
  • Cell replacement therapy
Licensing Contact:
Shmilovich, Michael
shmilovm@nih.gov
Phone: 301-435-5019