Technology ID
TAB-5141

Electrochemical Impedance Spectroscopy (EIS) for Non-Destructive Assessment of Epithelial Integrity

E-Numbers
E-203-2023-0
Lead Inventor
Maminishkis, Arvydas
Lead IC
NEI
Co-Inventors
Bharti, Kapil
Forest, Craig
Lewallen, Colby
ICs
NEI
Applications
Research Materials
Medical Devices
Diagnostics
Therapeutic Areas
Oncology
Infectious Disease
Development Stages
Prototype

This technology includes a novel apparatus and method that utilizes Electrochemical Impedance Spectroscopy (EIS) to assess the integrity of epithelial cell membranes non-destructively. By applying frequency-modulated voltage signals and facilitating fluid exchange on both sides of the epithelial tissue, this technology allows researchers to characterize membrane-specific responses with unprecedented accuracy. This advancement opens new avenues for drug discovery and evaluation of stem cell therapies, making it a vital tool for both academic and commercial research.

 

Potential Commercial Applications

  • Assessment of drug effects on epithelial cells in pharmaceutical research.
  • Standardized evaluation of stem cell therapies targeting epithelial tissues.
  • Research into epithelial physiology and pathology in various medical fields.

 

Competitive Advantages

  • Non-invasive technique that preserves tissue integrity, allowing for repeated measurements.
  • High-throughput capability enables faster drug discovery and evaluation processes.
  • Reduces reliance on traditional invasive methods, making it accessible to a broader range of researchers.
Licensing Contact:
Fenn, Edward (Tedd)
tedd.fenn@nih.gov