This technology includes a gene-based magnetic resonance imaging (MRI) reporter platform that harnesses adeno-associated virus (AAV) delivery of the metal transporter Zip14 to create image contrast wherever the gene is expressed. By driving Zip14 from cell-specific promoters, investigators obtain robust, long-lasting signal changes on standard clinical MRI sequences (e.g., MPRAGE and GRE), enabling real-time visualization of living cells and their gene-expression patterns. Because no external contrast agents, exotic pulse sequences, or tissue implantation steps are required, the system simplifies longitudinal studies and reduces safety concerns. The modular design supports rapid retargeting to other tissues, providing a scalable solution for tracking gene-therapy vectors, regenerative processes, or engineered cell therapies. Overall, Zip14-AAV reporters bridge the gap between molecular biology and routine radiology, opening a clear path toward clinically translatable, image-guided therapeutics.