Cyclic Peptides as Non-Hormonal Male Contraceptive Agents and Methods of Use Thereof

The available options for male contraceptives are limited. Current research is focused mainly on hormonal male contraceptives. This technology is a potential non-hormonal contraceptive using cyclic peptides to prevent spermatogenesis or the process of generating sperm within the male reproductive organs.  Specifically, this technology describes the development of a class of cyclic peptides inhibiting phosphorylation of gonadotropin-regulated testicular helicase (GRTH/DDX25).

Silicone Hydrogel Support Structures that Mimic Tissue Vasculature for Cell Culturing

Researchers at the National Cancer Institute developed silicone hydrogel support structures that mimic tissue vasculature (e.g., capillary bed) with high oxygen diffusivity. Photolithographic methods are used to construct mimetic silicone hydrogel pillars that have, for example, a 20:1 height to diameter ratio. Advantageously, these mimetic silicone hydrogels diffuse oxygen from the bottom chamber to the cells cultured on the surface at near physiological rates (60 times that of water).

Device for selectively removing cells from a biological sample

A variety of techniques have been used to isolate specific cells or cell populations from a histological sample under direct microscopic visualization.  Techniques that involve manual or micro-manipulation devices to isolate individual cells based upon visible characteristics and/or immunological staining are labor intensive and can require an extended amount of time.

Zirconium-89 PET Imaging Agent for Cancer

Researchers at the NCI Radiation Oncology Branch  and NIH CIT Center for Molecular Modeling developed a tetrahydroxamate chelation technology that provides a more-stable Zr-89 complex as an immuno-PET cancer imaging agent. In either the linear or the macrocyclic form, the tetrahydroxamate complexes exhibit greater stability as chelating agents compared to Zr-89 complexed to the siderophore desferrioxamine B (DFB), a trihydroxamate, which represents the current s