Public Teleconference with Dr. Constantine Stratakis of the National Institute of Child Health and Human Development to discuss the development of PDE11A as a novel therapeutic target for inherited form of Cushing syndrome and endocrine tumors

This technology identifies a new form of Cushing syndrome, "isolated micronodular adrenocortical disease" (iMAD), classified as a rare disease, as well as the role of PDE11A gene in this disease. Particular sequence variants of the PDE11A gene associated with abnormal or altered function of the gene have been identified. These variants are present in higher proportion in patients with iMAD, as well as in patients with other adrenal tumors. A detailed technology description was published in the Federal Register on February 21, 2007 [72 FR 7895].

Collaborative research opportunities and licensing opportunities will also be discussed.

Date and Time: Thursday, April 5, 2007 at 2 PM (EDT)

Contact: Mojdeh Bahar (; Phone: 301-435-2950) for details and Call-in instructions.