FY-2016 Top 20 Commercially Successful Inventions

(based on royalties on product sales)

photo: syringe, ampoules VACCINES & THERAPEUTICS
1 Novel Protease Inhibitor for Treatment of Drug-Resistant HIV-1 Erickson et al. NCI
2 HPV Vaccines Based Upon Recombinant Papillomavirus Capsid Proteins Lowy et al. NCI
3 Proteosome Inhibitor for Treatment of Multiple Myeloma Gupta et al. NCI
4 Nutritional Supplement to Treat Macular Degeneration Ferris et al. NEI
9 Palifermin for Treatment of Oral Mucositis Rubin et al. NCI
11 Vaccine for Dengue Virus Lai et al. NIAID
18 Development of Human Monoclonal Antibodies and Antibody Drug Conjugates Against CD276 as Cancer Diagnostics and Therapeutic Agents Dimitrov et al. NCI
19 Chimeric Antigen Receptors Targeting B-cell Maturation Antigen Kochenderfer NCI
photo: human puzzle with stethoscope DIAGNOSTICS
6 DNA Probe for Breast Cancer Diagnosis (HER-2) King et al. NCI
8 Human Immunodeficiency Viruses Associated with AIDS, A Diagnostic Method for AIDS and Pre-AIDS, A Kit Therefor Montagnier et al. NCI
14 Process for Producing Monoclonal Antibodies Reactive with Human Breast Cancer Schlom et al. NCI
16 Parvovirus Capsids Young et al. NHLBI
abstract illustration: instrumentation INSTRUMENTATION & DEVICES
10 Transcranial Magnetic Stimulation System Zangen et al. NIDA
12 Laser Capture Microdissection Liotta et al. NCI
photo: laboratory glassware RESEARCH MATERIALS
5 Monoclonal Hybridoma Cell Lines Murphy et al. NIAID
7 Digital PCR Silver et al. NIAID
13 Monoclonal Antibody Reactive with Human Breast Cancer (TAG72) Schlom et al. NCI
15 Cloning, Expression and Diagnosis of Human Cytochrome P450 2C19 Goldstein et al. NIEHS
17 Mouse Expressing Enhanced Signaling for Bone Morphogenetic Protein (BMP): A Model For Human Disease Mishina et al. NIEHS
20 Synthetic Peptides for the Production of Specific Keratin Protein Antibodies Yuspa et al. NCI