Derivatives of Docosahexaenoylethanolamide (DEA) for Neurogenesis
Small Interfering RNA Inhibition of Cannabanoid-1 Receptor (CB1R) for Treating Type 2 Diabetes
Cannabinoid Receptor Meditating Compounds for Metabolic Disease
Synthesis and Characterization of d8-JD5037 for Drug Discovery Studies
This technology includes synthesis of S-2-((S)-3-(4-chlorophenyl)-N'-((4-chlorophenyl) sulfonyl)-4-phenyl-4,5-dihydro-1 H-pyrazole-1-carboximidamido)- 3-(methyld3) butanamide-d5, octadeuterated JD5037 for possible use in clinical Absorption, Distribution, Metabolism, and Excretion (ADME) studies for drug discovery studies.
Discovery of Novel SHT (SHT6) Compounds for the Treatment of Central Nervous System-related Diseases
This technology includes novel compounds which can be expected to selectively target the 5HT6 receptor, which is implicated in CNS-related diseases. In particular 5HT6 antagonism has been implicated in cognitive impairment, AD/PD and drug abuse/alcohol abuse related disorders. 5HT6 compounds have also shown to reduce appetite and induce weight loss. As such, compounds that can selectively antagonize 5HT6 along with an additional signaling pathway implicated in such diseases like inducible nitric oxide synthase (iNOS) may be valuable for such CNS mediated diseases.
Intralipid as a Contrast Agent to Enhance Subsurface Blood Flow Imaging
This technology includes a blood flow imaging method that allows for a higher density of smaller particles to be detected. Current imaging methods that are based on Doppler measurements are limited by the discontinuity in the capillary flow in the space between red blood cells. The core technology is to use a scattering agent to enhance capillary flow or microcirculation. This technology has been tested for optical coherence Doppler tomography, but can be expended to any Doppler based flow imaging techniques such as laser speckle imaging.
A Single Feedstock Process for the Production of Ketone Esters
This technology includes a process using a single feedstock of poly-p-hydroxybutyrate to provide all components necessary, and the means to combine them, to provide large quantities of ketone ester. Progress in research studies have been limited by the low amount and cost of ketone esters, however this process saves costs and expedites production.
Betty Tong
Dr. Tong obtained her Ph.D. in Molecular Biology from the University of Pennsylvania and studied transcription regulation during cell cycle and myeloid cell differentiation for her thesis. After completion of her graduate studies, she received a National Research Service Award and conducted postdoctoral research at Harvard Medical School and MIT. Dr. Tong also had several years of working experience in biotech industry and is registered to practice before the U.S. Patent and Trademark Office.