Technology ID
TAB-96

Laminin A Peptides

E-Numbers
E-246-1988-0
Lead IC
NIDCR
Co-Inventors
Kleinman, Hynda
ICs
NIDCR
Applications
Research Materials
Therapeutic Areas
Oncology
This invention relates to peptides and derivatives thereof having laminin-like activity, as well as a pharmaceutical composition of the peptide. The peptides claimed include Serine-Isoleucine-Lysine-Valine-Alanine-Valine (SIKVAV). Methods for promoting increased adhesion and migration of epithelial cells is also disclosed. The peptides have wide usage in research, nerve regeneration and cancer treatment. For example, this invention may be useful as an adhesion and regeneration agent for nerve guides and as an adhesion agent for vascular prosthesis.
Commercial Applications
  • adhesion agent
  • cancer therapeutic
  • research reagent
Competitive Advantages
  • key extracellular matrix component
  • widespread biological activity

Request More Info

Licensing Contact:
Knezevic, Vladimir
vlado.knezevic@nih.gov

Related Inventions

  • E-521-1986-3

Patents

  • US Patent 5,211,657
    Filed on 1988-11-07
    Status: Expired
  • Patent Cooperation Treaty
    (PCT) PCT/US1989/004871
    Filed on 1989-11-06
    Status: Administratively Closed
  • US
    Divisional (DIV) 07/530,969
    Filed on 1990-05-30
    Status: Abandoned
  • US
    File wrapper continuation (FWC) 08/411,067
    Filed on 1995-03-27
    Status: Abandoned

Publications

  • JJ Barchi, P Russ, B Johnson, A Otaka, M Nomizu, Y Yamada. Glycosylation of the active sequence Ser-Ile-Lys-Val-Ala-Val from (1 chain of laminin reduces tumor cell attachment activity. Bioorganic Medinal Chem Lett 5:711, 1995.
  • MC Kibbey, B Johnson, R Petryshyn, M Jucker, HK Kleinman. A 110-kD nuclear shuttling protein, nucleolin, binds to the neurite-promoting IKVAV site of laminin-1. J Neurosci Res 1995 Oct 15;42(3):314-22.
  • RS Bresalier, B Schwartz, YS Kim, QY Duh, HK Kleinman, PM Sullam. The laminin alpha 1 chain Ile-Lys-Val-Ala-Val (IKVAV)-containing peptide promotes liver colonization by human colon cancer cells. Cancer Res 1995 Jun 1;55(11):2476-80.
  • M Nomizu, BS Weeks, CA Weston, WH Kim, HK Kleinman, Y Yamada. Structure-activity study of a laminin alpha 1 chain active peptide segment Ile-Lys-Val-Ala-Val (IKVAV). FEBS Lett 1995 May 29;365(2-3):227-3.
  • MC Kibbey, ML Corcoran, LM Wahl, HK Kleinman. Laminin SIKVAV peptide-induced angiogenesis in vivo is potentiated by neutrophils. J Cell Physiol 1994 Jul;160(1):185-93.
  • BS Weeks, E Holloway, PE Klotman, SK Akiyama, HW Schnaper, HK Kleinman. 12-O-tetradecanoylphorbol 13-acetate stimulates human T-lymphocyte adherence to the fibronectin RGD domain and the laminin IKVAV domain. Cell Immunol 1994 Jan;153(1):94-104.

Collaborations

  • Licensing

License Status

  • Available for licensing.
Date Published