Technology Bundle ID
TAB-788

Mouse Lacking the Chemokine Receptor CX3CR1

Applications
Linked ID
E-216-2003-0
Lead Inventors
Philip Murphy (NIAID)
Co-Inventors
Jiliang Gao (NIAID)
ICs
This mouse has been generated by targeted gene disruption. The mouse provides a model to investigate the function of the chemokine receptor CX3CR1, which is a proinflammatory receptor for the leukocyte chemoattractant CX3CL1 (aka fractalkine). As an example, the mouse is in use in the study of atherosclerosis. Further, the mouse may serve as a model study the role of the immune system during infection with pathogens as well as other immunologically mediated diseases and responses to tumors.

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