Technology Bundle ID
TAB-3705

TBK1 and NDP52/OPTN Double Knockout Cell Lines for Studying Mitochondrial Degradation Biology

Applications
Therapeutics
Linked ID
E-103-2016-0
Lead Inventors
Danielle Sliter (NINDS)
Co-Inventors
Richard Youle (NINDS)
ICs
NINDS
This technology includes the generation and use of HeLa cell lines that have the TANK-binding kinase 1 (TBK1) gene knocked out solely or in combination with either the genes NDP52 or OPTN. Both NDP52 and OPTN are receptors involved in the degradation of mitochondria, mitophagy. The TBK1 kinase has a role in enhancing the effect of mitophagy on these receptors. Mutations in TBK1 have been shown to be associated with neurodegenerative diseases such as Parkinson, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS).
Commercial Applications
This discovery allows for exploration into the specific function of NDP52 and Optineurin(OPTN)/TBK1 in mitochondrial degradation (mitophagy).
Competitive Advantages
There are no other double knockout mice to study the role of these mitophagy-related genes.

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